Spark research

Doron Melamed - Fc-E is a novel compound for developing drugs to abolish allergies.

Allergies affect about 40% of the population in developed world. Allergy may result in a local hypersensitivity response, but often develops into a severe systemic reaction that may lead to anaphylaxis and even death.

Simone Englender - A novel decoy peptide that prevents a-synuclein pathology in Parkinson's disease models: a potential new therapy for Parkinson’s disease and other a-synucleinopathies

Parkinson's disease (PD) is a common neurodegenerative disorder that affects millions of people worldwide, and there is no treatment that can halt its progression. Neuronal death are due to the accumulation and aggregation of a-synuclein.

Haguy Wolfenson & Peleg Hasson - The use of fibronectin fibrillogenesis inhibitors in vivo as novel anti-fibrotic drugs

Following the success of our previous Translational Research Grant, in this extension request we are proposing to use inhibitors of fibronectin (FN) fibrillogenesis that we have developed to test their activity in vivo.