Pre-clinical and Clinical research

Shai Shen-Orr, Tsila Zuckerman, Shlomit Yehudai-Reshef - IMM-AGE Metrics in BMT: Advancing Predictive Tools for Graft-versus-Host Disease Mitigation in AML patients

The immune system's role in health and disease is influenced by genetics and lifelong exposure to diverse stimuli, resulting in significant individual variability. However, this diversity is not integrated into bone marrow transplantation (BMT), a last-line treatment for Acute Myeloid Leukemia (AML) patients.

Naama Geva-Zatorsky, Mical Paul - The association between the gut microbiome characteristics and changes leading to Carbapenem Resistant Enterobacterales (CRE) acquisitions and the risk for a clinical infection caused by CRE after the acquisition.

Infections caused by carbapenem-resistant Enterobacterales (CRE) incur unacceptable mortality. Clinical infections arise from CRE colonizing the gut. While much has been studied on clinical risk factors favoring the acquisition of CRE colonization and transition from colonization to infection, little has been studied on the microbiome features preceding such events.

Sara Selig, Noam Kaplan - Disruption of histone homeostasis in cancer by NPAT

Histones are proteins that both form the fundamental unit of DNA packaging and regulate genomic activity. In cancer, the balance between canonical histones and various functional histone variants is swayed, playing a key role in supporting cancer progression and proliferation.

Dori Derdikman, Eyal Raz - Effect of sedative drugs on hippocampal associative-memory drift

This proposal will examine the impact of anesthetic drugs on memory processes during sedation and general anesthesia. Accidental awareness with recall is a rare yet significant occurrence.