Our lab investigates the molecular mechanisms that lead to Parkinson’s disease. We study the main proteins involved in the disease, including a-synuclein, LRRK2 and PINK1. We discovered that ubiquitination and SUMOylation regulate a-synuclein degradation and aggregation. Also, that LRRK2 helps maintain nuclear lamina organization, and synphilin-1, in concert with PINK1, represents a novel pathway to promote mitophagy.