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Yuval Shaked, PhD

Assistant Professor of Molecular Pharmacology

PhD, 2004 - Hebrew University, Israel

The double-edged sword of cancer therapy

Anti-cancer therapies, including chemotherapy, radiation, surgery and targeted drugs, often generate host responses that contribute to tumor outgrowth and relapse despite an initial successful therapy outcome. Tumor relapse due to host effects is attributed to angiogenesis, tumor cell repopulation, dissemination from the primary location, and seeding at metastatic sites. The therapy triggers host cell colonization at the primary tumor site and secretion of cytokines and growth factors that, in turn, promote tumor relapse and resistance to therapy.  In my laboratory we study the host responses generated by a variety of anti-cancer drug therapies and their attendant clinical implications.


Representative publications 

Beyar-Katz O and Shaked Y. 2014. Host effects contributing to cancer therapy resistance. Drug Resistance Updates. S1368-7646(14)00080-6.


Voloshin T, Voest EE, and Shaked, Y. 2013. The host immunological response to cancer therapy: an emerging concept in tumor biology. Experimental Cell Research S0014-4827(13)00115-8. (Cover).


Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer SJ, and Shaked Y. 2012. Tumor initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs. Stem Cells. 30, 1831-41.


Gingis-Velitski S, Loven D, Benayoun L, Munster M, Bril R, Voloshin T, Alishekevitz D, Bertolini F, and Shaked Y. 2011. Host response to short-term, single-agent chemotherapy induces matrix metalloproteinase-9 expression and accelerates metastasis in mice. Cancer Research. 71, 6986-96.


Voloshin T, Gingis-Veltski S, Milsom C, Man S, Munster M, Kerbel RS, and Shaked Y. 2011. G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist. Blood. 118, 3426-35.


Figure legend:


 Studying aspects of tumor-host interactions


Website: http://shakedlab.net.technion.ac.il

Email: yshaked@tx.technion.ac.il
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The Nobel Prize in Chemistry 2004

Professors Avram Hershko and Aaron Ciechanover - winners of the 2004 Nobel Prize in Chemistry.
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